11 November 2024
New paper on Integrator/ARMC5
New paper on Integrator/ARMC5 from the Svejstrup lab in Molecular Cell is online now!
Blears, Lou, et al. reveal that loss of functional Integrator in promoter-proximal regions is compensated for by ARMC5-dependent degradation of RNAPII. Disruption of both pathways results in transcription with high levels of elongation pausing, suggesting that promoter-proximal pausing constitutes an early transcription checkpoint for licensing of elongating RNAPII.